A Novel Scheme and Evaluations on a Long-Term and Continuous Biosensor Platform Integrated with a Dental Implant Fixture and Its Prosthetic Abutment
Identifieur interne : 000443 ( Pmc/Curation ); précédent : 000442; suivant : 000444A Novel Scheme and Evaluations on a Long-Term and Continuous Biosensor Platform Integrated with a Dental Implant Fixture and Its Prosthetic Abutment
Auteurs : Yu-Jung Li ; Chih-Cheng Lu [Taïwan]Source :
- Sensors (Basel, Switzerland) [ 1424-8220 ] ; 2015.
Abstract
A miniature intra-oral dental implant system including a built-in biosensor device is proposed in this article. The dental implant system, or platform, is replaced over maxilla and allows relatively non-invasive procedures for a novel biosensing scheme for human blood analysis. Due to placement of the implant fixture, periodontal ligaments and the pulp structure, which are regarded as the main origin of pain, are thus removed, and long-term, continuous blood analysis and management through maxillary bone marrow becomes achievable through the dental implant platform. The new pathway of biological sensing is for the first time presented to realize an accurate and painless approach without injections. The dental implant system mainly consists of an implant fixture and a prosthetic abutment, a biosensor module, a bluetooth 4.0 wireless module and a dc button cell battery. The electrochemical biosensor possesses three electrodes, including working, reference and counter ones, which are arranged to pass through the titanium implant fixture below the biosensor module. The electrodes are exposed to the blood pool inside the maxillary bone marrow and perform oxidation/reduction reactions with the coating of biosensing enzyme. To prove the proposed platform, the immobilization process of glucose oxidase (GOD) enzyme and
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DOI: 10.3390/s151024961
PubMed: 26404283
PubMed Central: 4634461
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A Novel Scheme and Evaluations on a Long-Term and Continuous Biosensor Platform Integrated with a Dental Implant Fixture and Its Prosthetic Abutment</title><author><name sortKey="Li, Yu Jung" sort="Li, Yu Jung" uniqKey="Li Y" first="Yu-Jung" last="Li">Yu-Jung Li</name><affiliation><nlm:aff id="af1-sensors-15-24961">Graduate Institute of Mechanical and Electrical Engineering, National Taipei University of Technology, Taipei 10608, Taiwan; E-Mail:<email>richard513.tw@yahoo.com.tw</email></nlm:aff></affiliation></author><author><name sortKey="Lu, Chih Cheng" sort="Lu, Chih Cheng" uniqKey="Lu C" first="Chih-Cheng" last="Lu">Chih-Cheng Lu</name><affiliation><nlm:aff id="af1-sensors-15-24961">Graduate Institute of Mechanical and Electrical Engineering, National Taipei University of Technology, Taipei 10608, Taiwan; E-Mail:<email>richard513.tw@yahoo.com.tw</email></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-sensors-15-24961">Department of Mechanical Engineering, National Taipei University of Technology, Taipei 10608, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Mechanical Engineering, National Taipei University of Technology, Taipei 10608</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26404283</idno><idno type="pmc">4634461</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634461</idno><idno type="RBID">PMC:4634461</idno><idno type="doi">10.3390/s151024961</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000443</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000443</idno><idno type="wicri:Area/Pmc/Curation">000443</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000443</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A Novel Scheme and Evaluations on a Long-Term and Continuous Biosensor Platform Integrated with a Dental Implant Fixture and Its Prosthetic Abutment</title><author><name sortKey="Li, Yu Jung" sort="Li, Yu Jung" uniqKey="Li Y" first="Yu-Jung" last="Li">Yu-Jung Li</name><affiliation><nlm:aff id="af1-sensors-15-24961">Graduate Institute of Mechanical and Electrical Engineering, National Taipei University of Technology, Taipei 10608, Taiwan; E-Mail:<email>richard513.tw@yahoo.com.tw</email></nlm:aff></affiliation></author><author><name sortKey="Lu, Chih Cheng" sort="Lu, Chih Cheng" uniqKey="Lu C" first="Chih-Cheng" last="Lu">Chih-Cheng Lu</name><affiliation><nlm:aff id="af1-sensors-15-24961">Graduate Institute of Mechanical and Electrical Engineering, National Taipei University of Technology, Taipei 10608, Taiwan; E-Mail:<email>richard513.tw@yahoo.com.tw</email></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-sensors-15-24961">Department of Mechanical Engineering, National Taipei University of Technology, Taipei 10608, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Mechanical Engineering, National Taipei University of Technology, Taipei 10608</wicri:regionArea></affiliation></author></analytic><series><title level="j">Sensors (Basel, Switzerland)</title><idno type="eISSN">1424-8220</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>A miniature intra-oral dental implant system including a built-in biosensor device is proposed in this article. The dental implant system, or platform, is replaced over maxilla and allows relatively non-invasive procedures for a novel biosensing scheme for human blood analysis. Due to placement of the implant fixture, periodontal ligaments and the pulp structure, which are regarded as the main origin of pain, are thus removed, and long-term, continuous blood analysis and management through maxillary bone marrow becomes achievable through the dental implant platform. The new pathway of biological sensing is for the first time presented to realize an accurate and painless approach without injections. The dental implant system mainly consists of an implant fixture and a prosthetic abutment, a biosensor module, a bluetooth 4.0 wireless module and a dc button cell battery. The electrochemical biosensor possesses three electrodes, including working, reference and counter ones, which are arranged to pass through the titanium implant fixture below the biosensor module. The electrodes are exposed to the blood pool inside the maxillary bone marrow and perform oxidation/reduction reactions with the coating of biosensing enzyme. To prove the proposed platform, the immobilization process of glucose oxidase (GOD) enzyme and <italic>in vitro</italic> detections of glucose levels are successfully carried out, and proven sensitivity, linearity and repeatability of the glucose biosensor system are obtained. Moreover, a preliminary canine animal model adopting the new pathway shows significant consistency with the traditional method through dermal pricks for blood sugar detection. Despite the prospective results, further challenges in engineering implementation and clinical practices are addressed and discussed. In brief, the novel biosensing pathway and intra-oral biosensor platform may increasingly reveal their promising value and feasibilities in current bio-medical analysis, diagnosis, drug release and even healthcare technologies.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Newby, L K" uniqKey="Newby L">L.K. Newby</name></author><author><name sortKey="Goldmann, B U" uniqKey="Goldmann B">B.U. Goldmann</name></author><author><name sortKey="Ohman, E M" uniqKey="Ohman E">E.M. Ohman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="David, C" uniqKey="David C">C. David</name></author><author><name sortKey="Mcgee, M D" uniqKey="Mcgee M">M.D. McGee</name></author><author><name sortKey="Michael, K G" uniqKey="Michael K">K.G. Michael</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weng, J" uniqKey="Weng J">J. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Sensors (Basel)</journal-id><journal-id journal-id-type="iso-abbrev">Sensors (Basel)</journal-id><journal-id journal-id-type="publisher-id">sensors</journal-id><journal-title-group><journal-title>Sensors (Basel, Switzerland)</journal-title></journal-title-group><issn pub-type="epub">1424-8220</issn><publisher><publisher-name>MDPI</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26404283</article-id><article-id pub-id-type="pmc">4634461</article-id><article-id pub-id-type="doi">10.3390/s151024961</article-id><article-id pub-id-type="publisher-id">sensors-15-24961</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>A Novel Scheme and Evaluations on a Long-Term and Continuous Biosensor Platform Integrated with a Dental Implant Fixture and Its Prosthetic Abutment</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Li</surname><given-names>Yu-Jung</given-names></name><xref ref-type="aff" rid="af1-sensors-15-24961">1</xref></contrib><contrib contrib-type="author"><name><surname>Lu</surname><given-names>Chih-Cheng</given-names></name><xref ref-type="aff" rid="af1-sensors-15-24961">1</xref><xref ref-type="aff" rid="af2-sensors-15-24961">2</xref><xref rid="c1-sensors-15-24961" ref-type="corresp">*</xref></contrib></contrib-group><contrib-group><contrib contrib-type="editor"><name><surname>Star</surname><given-names>Alexander</given-names></name><role>Academic Editor</role></contrib></contrib-group><aff id="af1-sensors-15-24961"><label>1</label>Graduate Institute of Mechanical and Electrical Engineering, National Taipei University of Technology, Taipei 10608, Taiwan; E-Mail:<email>richard513.tw@yahoo.com.tw</email></aff><aff id="af2-sensors-15-24961"><label>2</label>Department of Mechanical Engineering, National Taipei University of Technology, Taipei 10608, Taiwan</aff><author-notes><corresp id="c1-sensors-15-24961"><label>*</label>Author to whom correspondence should be addressed; E-Mail: <email>cclu23@ntut.edu.tw</email>; Tel.: +886-2-2771-2171 (ext. 2067).</corresp></author-notes><pub-date pub-type="epub"><day>25</day><month>9</month><year>2015</year></pub-date><pub-date pub-type="collection"><month>10</month><year>2015</year></pub-date><volume>15</volume><issue>10</issue><fpage>24961</fpage><lpage>24976</lpage><history><date date-type="received"><day>26</day><month>6</month><year>2015</year></date><date date-type="accepted"><day>10</day><month>9</month><year>2015</year></date></history><permissions><copyright-statement>© 2015 by the authors; licensee MDPI, Basel, Switzerland.</copyright-statement><copyright-year>2015</copyright-year><license><license-p><pmc-comment>CREATIVE COMMONS</pmc-comment>This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>).</license-p></license></permissions><abstract><p>A miniature intra-oral dental implant system including a built-in biosensor device is proposed in this article. The dental implant system, or platform, is replaced over maxilla and allows relatively non-invasive procedures for a novel biosensing scheme for human blood analysis. Due to placement of the implant fixture, periodontal ligaments and the pulp structure, which are regarded as the main origin of pain, are thus removed, and long-term, continuous blood analysis and management through maxillary bone marrow becomes achievable through the dental implant platform. The new pathway of biological sensing is for the first time presented to realize an accurate and painless approach without injections. The dental implant system mainly consists of an implant fixture and a prosthetic abutment, a biosensor module, a bluetooth 4.0 wireless module and a dc button cell battery. The electrochemical biosensor possesses three electrodes, including working, reference and counter ones, which are arranged to pass through the titanium implant fixture below the biosensor module. The electrodes are exposed to the blood pool inside the maxillary bone marrow and perform oxidation/reduction reactions with the coating of biosensing enzyme. To prove the proposed platform, the immobilization process of glucose oxidase (GOD) enzyme and <italic>in vitro</italic> detections of glucose levels are successfully carried out, and proven sensitivity, linearity and repeatability of the glucose biosensor system are obtained. Moreover, a preliminary canine animal model adopting the new pathway shows significant consistency with the traditional method through dermal pricks for blood sugar detection. Despite the prospective results, further challenges in engineering implementation and clinical practices are addressed and discussed. In brief, the novel biosensing pathway and intra-oral biosensor platform may increasingly reveal their promising value and feasibilities in current bio-medical analysis, diagnosis, drug release and even healthcare technologies.</p></abstract><kwd-group><kwd>dental implant system</kwd><kwd>intra-oral biosensor platform</kwd><kwd>glucose oxidase (GOD)</kwd><kwd>blood sugar level</kwd><kwd>Diabetes Mellitus (DM)</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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